Coding

Part:BBa_K3096010

Designed by: Lina Widerspick Famke Baeuerle, Patrick Mueller, Jakob Keck   Group: iGEM19_Tuebingen   (2019-10-14)

YTA2 - cell penetrating peptide

YTA2 is a synthetic cell-penetrating peptide (CPPs), which allows mediating the transport of cargo proteins across the cell membrane. Unlike many other YTA2 does not have to be chemically linked with the cargo molecule to mediate its transport. Simple coincubation of YTA2, the cargo molecule, and the cell is sufficient.

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]

Biosafety

Together with professional safety officials, Team iGEM Tuebingen 2019 has evaluated the biosafety of cell penetrating peptides and has come to the conclusion that cell penetrating peptides are to be classified as BSL1.

References

  1. Myrberg, Helena, Maria Lindgren, and Ülo Langel. "Protein delivery by the cell-penetrating peptide YTA2." Bioconjugate chemistry 18.1 (2007): 170-174.


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Categories
Parameters
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